External & Synthetic Control Arm Studies Vendors
Construction and analysis of external or synthetic comparator cohorts from non-randomized data to contextualize outcomes for a treated study population.
Related workflows
Data / Intelligence Provider · +3 more types
Products: TriNetX LIVE, TriNetX Dataworks +5 more
“Based on a proven methodology built upon 30+ years of experience, TriNetX external control arms (ECAs) help you with timely, representative, granular, and fit-for-purpose control…”Source: trinetx.com
Also offers: Real-World Data Platform, Real-World Evidence Analytics, +2 more
CRO / Research Services Provider · +2 more types
Products: InStat, CoAuthor
“Data and information from a natural history study can provide an untreated, external control group for use as the comparator to the treatment group(s) in an investigational drug…”Source: veristat.com
Also offers: Biostatistics & Statistical Programming, Full-Service Clinical Trial Execution (CRO Services), +3 more
CRO / Research Services Provider · +7 more types
Products: IQVIA Vigilance Platform, SmartSolve +4 more
“External comparators provide meaningful context in single arm studies, where comparison to placebo is impractical or unethical. They are also used to contextualize clinical trial…”Source: iqvia.com
Also offers: Full-Service Clinical Trial Execution (CRO Services), Real-World Data Platform, +6 more
Agency · +3 more types
“Comparative effectiveness (including external control arms)”Source: costellomedical.com
Also offers: HTA Strategy & Submissions, Health Economic Modeling, +3 more
Software / Technology Platform · +3 more types
Products: Healthcare Map, Marmot +9 more
“Use our research-grade real-world data to create retrospective control arms to further understand the impact of a therapy.”Source: komodohealth.com
Also offers: Real-World Data Platform, Patient Journey & Population Analytics, +1 more
Consulting / Advisory Firm · +4 more types
Products: Lumanity Illuminator, Evidence Illuminator +9 more
“Comparative effectiveness, including synthetic control arms”Source: lumanity.com
Also offers: Market Access Strategy & Launch Planning, Brand Strategy & Positioning, +2 more
Compare listed vendors
| Vendor | Delivery model | Also offers | In their words |
|---|---|---|---|
| Costello Medical | Agency | — | “Comparative effectiveness (including external control arms)”costellomedical.com · reviewed Oct 14, 2026 |
| IQVIA | CRO / Research Services Provider | — | “External comparators provide meaningful context in single arm studies, where comparison to placebo is impractical or unethical. They are also used to…”iqvia.com · reviewed Oct 19, 2026 |
| Komodo Health | Software / Technology Platform | Comparative Effectiveness Research | “Use our research-grade real-world data to create retrospective control arms to further understand the impact of a therapy.”komodohealth.com · reviewed Oct 24, 2026 |
| Lumanity | Consulting / Advisory Firm | — | “Comparative effectiveness, including synthetic control arms”lumanity.com · reviewed Oct 21, 2026 |
| TriNetX | Data / Intelligence Provider | Comparative Effectiveness Research | “Based on a proven methodology built upon 30+ years of experience, TriNetX external control arms (ECAs) help you with timely, representative, granular, and…”trinetx.com · reviewed Oct 26, 2026 |
| Veristat | CRO / Research Services Provider | — | “Data and information from a natural history study can provide an untreated, external control group for use as the comparator to the treatment group(s) in an…”veristat.com · reviewed Oct 26, 2026 |