Simulations Plus

Simulations Plus provides model-informed drug development (MIDD) software and consulting, supporting ADMET prediction, PBPK, pharmacometrics, and QSP and quantitative systems toxicology from discovery through commercialization. It also offers AI-enabled discovery, regulatory planning, protocol optimization and site training, medical communications, and stakeholder insights.

Model-Informed Development

• Guide dose selection and development decisions with PBPK, population PK, exposure-response, and other pharmacometric analyses. Simulations Plus provides PBPK modeling and simulation consulting for drug absorption and disposition; GastroPlus is its mechanistic simulation software for absorption, biopharmaceutics, pharmacokinetics, and pharmacodynamics across dosing routes in humans and animals, and Composer is its AI platform for asking MIDD questions in natural language.
• Build model-informed development programs using pharmacometric analysis, QSP models, and clinical-data simulations. Thales is a QSP platform for building models, optimizing simulated populations to clinical datasets, and analyzing simulation results. QSP Flex licenses validated QSP models for a team's own environment, and DILIsym is quantitative systems toxicology software for drug-induced liver injury risk.

Computational Discovery and Pharmacology

• Explore and prioritize novel compounds with AI-driven design, predictive models, mechanistic insight, and computational chemistry workflows. ADMET Predictor supports scaffold clustering, R-group analysis, and MCDA-based lead prioritization; MedChem Designer™ combines molecule drawing with ADMET property predictions.
• Support preclinical and clinical pharmacology decisions with PK/TK, clinical PK/PD, population PK, and first-in-human analyses. Services include noncompartmental analysis, population modeling, exposure-response assessment, and PBPK-based dosing strategies. MonolixSuite is its pharmacometric modeling and simulation suite, and KIWI is a validated cloud platform for organizing and sharing pharmacometric results and NONMEM runs.

Clinical, Regulatory, and Trial Readiness

• Design and refine clinical protocols by translating scientific and regulatory documents into interactive patient-journey simulations that include site operational flow. Simulations Plus also develops regulatory strategies for drug-development programs and prepares pharmacology sections for IND, CSR, briefing book, SAP, FTR, CTD, and NDA documents.
• Prepare clinical trial sites through simulation-based training for sponsors and CROs. Pro-ficiency is a learning platform that houses complex training content, while the company also delivers accredited simulation-based education grounded in real-world use.

Medical Affairs and Stakeholder Insight

• Generate stakeholder insights through market research, advisory boards, focus groups, KOL mapping, and engagement strategy. Panorama KOL Insights is a dashboard for finding influential industry leaders using filters such as therapeutic expertise, affiliation, and geography.
• Translate scientific evidence into audience-specific communications and support investigator meetings, advisory boards, speaker programs, and scientific communication platforms for HCP audiences.

Best Fit

• Pharmaceutical and biotechnology teams seeking software and expert support for model-informed development, quantitative pharmacology, AI-enabled discovery, or dose and regimen decisions.