TriNetX

TriNetX connects healthcare organizations and researchers through a global network of more than 13,000 clinical sites in over 20 countries, and applies its real-world data and scientific analysis to protocol planning, site feasibility, evidence generation, and safety workflows. Its platform provides downloadable de-identified EHR data, supports genomic analysis, and includes research services for epidemiology, HEOR, and comparative effectiveness.

Real-World Data and Evidence

• Use research-ready data for analysis: TriNetX Dataworks provides downloadable, row-level, de-identified EHR patient data in a ready-to-use format. TherapyMonitor provides patient-level insights from European oncology data for study objectives.
• Generate evidence for treatment and access decisions through real-world evidence analytics, comparative effectiveness research, retrospective database studies, epidemiology services, and HEOR studies. TriNetX supports analyses of intervention value, healthcare utilization, patient journeys, disease burden, and progression.

Protocol and Trial Planning

• Test protocol criteria and assess sites before study activation: TriNetX Terrain provides a connected evidence layer for evaluating feasibility hypotheses against real-world patient data, including genomic and biomarker profiles and unstructured clinical notes.
• Identify eligible populations and engage sites for recruitment. TriNetX LIVE supports criteria testing, site identification, and direct engagement with healthcare organizations, sites, and investigators to identify patients and reduce site burden. TriNetX LIVE Connect brings sponsors, CROs, and healthcare organizations together on one secure platform, with tools for communication, document exchange, and trial management.

Specialized Analytics and Safety

• Analyze genomic and multimodal datasets for biomarker discovery, patient stratification, variant analysis, and translational research through XetaBase, which supports secure analysis and harmonization of these datasets.
• Combine EHR data with claims, pharmacy fills, cost data, and mortality through TriNetX Linked, and link records to tumor registries, genomic datasets, and biomarker repositories through privacy-preserving linkage. Track patient journeys over time and across care settings. EVIDEX calculates background adverse-event incidence rates and supports signal detection, assessment, management, reporting, and sharing in a validated platform.

Best Fit

• Best suited to biopharma, healthcare organizations, academic medical centers, research institutions, sponsors, CROs, and clinical operations teams that need real-world data, evidence generation, protocol planning, site strategy, or pharmacovigilance workflows.
• Teams can also use TriNetX for external control arms when randomized controls are impractical, using real-world patient data in lieu of additional recruitment, and for RWE strategy, study design, protocols, and statistical analysis plans.