VectorBuilder

VectorBuilder combines research services, product supply, and CDMO manufacturing for gene and cell therapy programs. Its offerings span vector and plasmid production, RNA/LNP manufacturing, biologics discovery, screening, and preclinical studies.

GMP Vector, Plasmid and RNA Manufacturing

• Develop and manufacture GMP AAV, lentiviral vectors, plasmid DNA, and IVT RNA, with process development, scale-up, QC, and batch release.
• Advance RNA therapeutics through LNP formulation, encapsulation, sterile filtration, and fill-finish within its CDMO manufacturing platform.
• Support filings with regulatory documentation, from strategy consultation on IND-enabling documents to CMC documentation for clinical trial and BLA filing.

Cell and Gene Therapy Development

• Support gene-therapy process development with cell banking, mammalian and microbial scale-up, technology transfer, and qualified analytical methods.
• Fill GMP drug substance or product into glass vials or cryobags using manual or automated aseptic filling for viral-vector programs.

Discovery and Preclinical Studies

• Discover and engineer therapeutic antibodies, CAR-based therapies, and oligonucleotide therapeutics through design, optimization, and functional testing.
• Construct and screen libraries, including CRISPR programs, and perform AAV biodistribution studies in rodents and nonhuman primates.

Best Fit

• Best suited to biotech and biopharma teams needing an integrated research, preclinical, or GMP development partner for vector and advanced-modality programs.
• Relevant buyers include teams moving gene, cell, or RNA therapeutics from discovery and preclinical work toward clinical manufacturing.